C0009508 - An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis. 1/10
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Terms, descriptions
CUI    C0009508
RussianMedical Subject Headings Russian D003178 L3353120preferred S3880582 Y КОМПЛЕМЕНТА КОМПОНЕНТА 3 НЕФРИТИЧЕСКИЙ ФАКТОР
RussianMedical Subject Headings Russian D003178 L0897290no S1101107 Y KOMPLEMENTA C3 NEFRITICHESKII FAKTOR
RussianMedical Subject Headings Russian D003178 L1512594no S1808503 Y C3 NEFRITICHESKII FAKTOR
RussianMedical Subject Headings Russian D003178 L2227584no S2565806 Y KOMPLEMENTA 3 NEFRITICHESKII FAKTOR
RussianMedical Subject Headings Russian D003178 L2227608no S2565830 Y KOMPLEMENTA KOMPONENTA 3 NEFRITICHESKII FAKTOR
RussianMedical Subject Headings Russian D003178 L3335249no S3862694 Y C3 НЕФРИТИЧЕСКИЙ ФАКТОР
RussianMedical Subject Headings Russian D003178 L3353084no S3880545 Y КОМПЛЕМЕНТА 3 НЕФРИТИЧЕСКИЙ ФАКТОР
RussianMedical Subject Headings Russian D003178 L5697476no S6530513 Y КОМПЛЕМЕНТА C3 НЕФРИТИЧЕСКИЙ ФАКТОР
Medical Subject Headings A8434689 AT115062670 An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.