C0167954 - A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0167954

Russian	Medical Subject Headings Russian	D020672	L5696595	preferred	S6529632	Y	I-КАППА B БЕЛКИ
Russian	Medical Subject Headings Russian	D020672	L1524020	no	S1819929	Y	I-KAPPA B
Russian	Medical Subject Headings Russian	D020672	L3335832	no	S3863346	Y	I-КАППА B
Russian	Medical Subject Headings Russian	D020672	L6967599	no	S8106721	Y	I-KAPPA B BELKI
	NCI Thesaurus				A7600119	AT224193762	A family of proteins that bind to the nuclear localization signal (NLS) domains of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) transcription factor complexes. This sequesters NF-kappaB in the cytoplasm and prevents its binding to the activation domains of target genes in the nucleus. Phosphorylation of I kappa B proteins, which is catalyzed by cytokine-activated I kappa B kinases (IKBK; IKK), disrupts binding to NF-kappaB and induces the degradation of I kappa B; this allows NF-kappaB to enter the nucleus and activate the transcription of target genes.
	Medical Subject Headings				A8405043	AT53894492	A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.