Classification Nuance. The OpenFDA dataset, which draws from the Structured Product Labeling (SPL) files, often includes multiple classification fields, and the specific string "Phosphate Binder [EPC]" may only be assigned to a single product. The other drugs are likely classified using: More Specific Classes: Many of those drugs (like sevelamer, ferric citrate, etc.) may be classified by their specific mechanism or chemical group, which also acts as a phosphate binder. Example: A drug might be classified as "Iron-Containing Compound [EPC]" or "Aluminum-Containing Compound [EPC]" instead of the more general "Phosphate Binder [EPC]". Different Classification Fields: The NDC data contains several classification fields. You might be checking the Established Pharmacological Class (pharm_class_epc), but the other drugs might be listed under: Mechanism of Action (pharm_class_moa), Physiological Effect (pharm_class_pe)
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Folate Analog Metabolic Inhibitor [EPC]

NDC Number Brand Name Generic Name Manufacturer Dosage Form DEA Sch. Marketing Start Date
0143-9367 Methotrexate Methotrexate Hikma Pharmaceuticals USA Inc. INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2005-09-06
0143-9516 Methotrexate Methotrexate Hikma Pharmaceuticals USA Inc. SOLUTION 2018-01-05
0143-9517 Methotrexate Methotrexate Hikma Pharmaceuticals USA Inc. SOLUTION 2018-01-05
0143-9518 Methotrexate Methotrexate Hikma Pharmaceuticals USA Inc. SOLUTION 2018-01-05
0143-9519 Methotrexate Methotrexate Hikma Pharmaceuticals USA Inc. SOLUTION 2017-10-10
0143-9830 Methotrexate Methotrexate Hikma Pharmaceuticals USA Inc. INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2005-09-06
0904-7141 Methotrexate Methotrexate Major Pharmaceuticals TABLET 2017-02-09
16729-277 Methotrexate Methotrexate Accord Healthcare, Inc. INJECTION 2014-03-07
52652-2001 Xatmep Methotrexate Azurity Pharmaceuticals, Inc. SOLUTION 2017-05-01
54436-010 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
54436-012 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
54436-015 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
54436-017 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
54436-020 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
54436-022 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
54436-025 Otrexup methotrexate Antares Pharma, Inc. INJECTION, SOLUTION 2013-10-11
65219-550 Pralatrexate Pralatrexate Fresenius Kabi USA, LLC INJECTION 2022-11-15
65219-552 Pralatrexate Pralatrexate Fresenius Kabi USA, LLC INJECTION 2022-11-15
68382-775 Methotrexate Methotrexate Zydus Pharmaceuticals USA Inc. TABLET 2017-02-09
70771-1058 Methotrexate Methotrexate Zydus Lifesciences Limited TABLET 2017-02-09
72893-003 Folotyn pralatrexate Acrotech Biopharma Inc INJECTION 2009-09-24
72893-005 Folotyn pralatrexate Acrotech Biopharma Inc INJECTION 2009-09-24
81927-204 JYLAMVO Methotrexate SHORLA ONCOLOGY INC. SOLUTION 2023-12-15
82497-010 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
82497-012 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
82497-015 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
82497-017 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
82497-020 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
82497-022 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
82497-025 Otrexup methotrexate Otter Pharmaceuticals, LLC INJECTION, SOLUTION 2024-09-25
83831-111 PEMETREXED DIPOTASSIUM pemetrexed dipotassium Avyxa Pharma, LLC INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2025-01-01
83831-112 PEMETREXED DIPOTASSIUM pemetrexed dipotassium Avyxa Pharma, LLC INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2025-01-01
83831-131 AXTLE pemetrexed Avyxa Pharma, LLC INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2025-01-01
83831-132 AXTLE pemetrexed Avyxa Pharma, LLC INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2025-01-01



 [EPC] Established Pharmacological Classification 

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